Lower cholesterol and inflammation levels with grape seed extract

Lower cholesterol and inflammation levels with grape seed extract

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The use of grape seed extract has already been tried against a wide variety of complaints. In a current meta-study, researchers have now evaluated the results of scientific studies on the subject and analyzed the effect of grape seed extract on blood sugar levels, blood lipid levels, inflammation markers in the blood and body weight. Particularly with regard to the cholesterol and the inflammation values, an extremely positive effect was shown.

The potential medical benefits of grape seed extract became clear, for example, in a 2017 study at the University of Colorado that found an inhibitory effect on prostate cancer. However, the available studies paint a very different picture of the health effects of grape seed extract. The new meta-study, the results of which have been published in the specialist magazine "Phytotherapy Research", tries to provide clarity regarding the metabolic effects of the extract.

Existing studies evaluated

Based on the published studies in online databases such as EMBASE, Scopus, PubMed, Cochrane Library and Web of Science, the international research team investigated the effects of grape seed extract on blood sugar, blood lipid levels, inflammation levels and body weight. The methodological quality of the included studies was also assessed. The researchers included a total of fifty studies.

Demonstrable effect of the extract

The data analysis showed that the intake of grape seed extract led to a significant decrease in fasting plasma glucose (fasting blood sugar), total cholesterol (especially bad LDL cholesterol), blood triglycerides and C-reactive proteins (CRP; inflammation markers) reports the research team.

No effects on body weight

According to the researchers, there were no effects on the HbA1c values ​​(long-term blood sugar), the HDL cholesterol level and the body weight or body fat. Anyone who relies on grape seed extract to lose weight can expect a bitter disappointment.

Further investigation required

However, according to the latest study results, the negative metabolic effects of being overweight may be somewhat offset by grape seed extract. The meta-analysis clearly showed that the levels of fasting blood sugar, total cholesterol, LDL cholesterol, triglycerides and the inflammation marker CRP were significantly reduced by taking the extract. Further studies must now clarify to what extent these effects can be used therapeutically. (fp)

Author and source information

This text corresponds to the specifications of the medical literature, medical guidelines and current studies and has been checked by medical doctors.

Dipl. Geogr. Fabian Peters


  • Omid Asbaghi, Behzad Nazarian, Željko Reiner, Elaheh Amirani, Fariba Kolahdooz, Maryam Chamani, Zatollah Asemi: The effects of grape seed extract on glycemic control, serum lipoproteins, inflammation, and body weight: A systematic review and meta-analysis of randomized controlled trials; in: Phytotherapy Research (published 12/26/2019),

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